Intra-droplet particle enrichment in a focused acoustic field

An intra-droplet particle switch for droplet microfluidics using bulk acoustic waves

To transfer cell- and bead-assays into droplet-based platforms typically requires the use of complex microfluidic circuits, which calls for methods to switch the direction of the encapsulated particles. We present a microfluidic chip where the combination of acoustic manipulation at two different harmonics and a trident-shaped droplet-splitter enables direction-switching of microbeads and yeast...

Particle Enrichment in Longitudinal Standing Bulk Acoustic Wave Microfluidics

A droplet in a stationary electric field

Water droplets on insulating material influence strongly the aging process of the material. The shape of the droplets signifies the state of the aging material. The present paper discusses a numerical procedure to calculate the droplet shape in an electric field generated by a constant voltage. A combined stationary solution of the droplet shape and the electric field is searched for. This lead...

Microfluidic droplet enrichment for targeted sequencing

Targeted sequence enrichment enables better identification of genetic variation by providing increased sequencing coverage for genomic regions of interest. Here, we report the development of a new target enrichment technology that is highly differentiated from other approaches currently in use. Our method, MESA (Microfluidic droplet Enrichment for Sequence Analysis), isolates genomic DNA fragme...

The Influence of Acoustic Field Induced by HRT on Oscillation Behavior of a Single Droplet

Can Ruan 1, Fei Xing 1,*, Yue Huang 1, Xinyi Yu 1, Jiacheng Zhang 1 and Yufeng Yao 2 1 School of Aerospace Engineering, Xiamen University, Xiamen 361005, Fujian, China; [email protected] (C.R.); [email protected] (Y.H.); [email protected] (X.Y.); [email protected] (J.Z.) 2 Department of Engineering Design and Mathematics, University of the West of England, Bristol...